Aspiration Pneumonia.
Semin Respir Crit Care Med
; 45(2): 237-245, 2024 Apr.
Article
em En
| MEDLINE
| ID: mdl-38211629
ABSTRACT
Aspiration pneumonia is a lower respiratory tract infection that results from inhalation of foreign material, often gastric and oropharyngeal contents. It is important to distinguish this from a similar entity, aspiration with chemical pneumonitis, as treatment approaches may differ. An evolving understanding of the human microbiome has shed light on the pathogenesis of aspiration pneumonia, suggesting that dysbiosis, repetitive injury, and inflammatory responses play a role in its development. Risk factors for aspiration events involve a complex interplay of anatomical and physiological dysfunctions in the nervous, gastrointestinal, and pulmonary systems. Current treatment strategies have shifted away from anaerobic organisms as leading pathogens. Prevention of aspiration pneumonia primarily involves addressing oropharyngeal dysphagia, a significant risk factor for aspiration pneumonia, particularly among elderly individuals and those with cognitive and neurodegenerative disorders.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pneumonia
/
Pneumonia Aspirativa
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Infecções Respiratórias
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Transtornos de Deglutição
Tipo de estudo:
Risk_factors_studies
Limite:
Aged
/
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article