Identification of cyclooxygenase-II inhibitory saponins from fenugreek wastes: Insights from liquid chromatography-tandem mass spectrometry metabolomics, molecular networking, and molecular docking.

Khalil, Asmaa M; Sabry, Omar M; El-Askary, Hesham I; El Zalabani, Soheir M; Eltanany, Basma M; Pont, Laura; Benavente, Fernando; Elshewy, Ahmed; Fayek, Nesrin M

Khalil, Asmaa M; Sabry, Omar M; El-Askary, Hesham I; El Zalabani, Soheir M; Eltanany, Basma M; Pont, Laura; Benavente, Fernando; Elshewy, Ahmed; Fayek, Nesrin M.

Afiliação

Khalil AM; Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Sabry OM; Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
El-Askary HI; Department of Pharmacognosy, Faculty of Pharmacy, Heliopolis University, Cairo, Egypt.
El Zalabani SM; Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Eltanany BM; Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Pont L; Department of Analytical Chemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Benavente F; Department of Chemical Engineering and Analytical Chemistry, Institute for Research on Nutrition and Food Safety (INSA-UB), University of Barcelona, Barcelona, Spain.
Elshewy A; Serra Húnter Program, Generalitat de Catalunya, Barcelona, Spain.
Fayek NM; Department of Chemical Engineering and Analytical Chemistry, Institute for Research on Nutrition and Food Safety (INSA-UB), University of Barcelona, Barcelona, Spain.

Phytochem Anal ; 35(4): 690-707, 2024 Jun.

Article em En | MEDLINE | ID: mdl-38212263

Assuntos

Inibidores de Ciclo-Oxigenase 2; Metabolômica; Simulação de Acoplamento Molecular; Saponinas; Espectrometria de Massas em Tandem; Trigonella; Trigonella/química; Saponinas/química; Saponinas/farmacologia; Saponinas/análise; Espectrometria de Massas em Tandem/métodos; Cromatografia Líquida/métodos; Metabolômica/métodos; Inibidores de Ciclo-Oxigenase 2/farmacologia; Inibidores de Ciclo-Oxigenase 2/química; Inibidores de Ciclo-Oxigenase 2/análise; Extratos Vegetais/química; Extratos Vegetais/farmacologia; Ciclo-Oxigenase 2/metabolismo

Palavras-chave

COX inhibitors; Trigonella foenumgraecum; metabolomics; molecular docking; saponins

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Saponinas / Trigonella / Inibidores de Ciclo-Oxigenase 2 / Espectrometria de Massas em Tandem / Metabolômica / Simulação de Acoplamento Molecular Tipo de estudo: Diagnostic_studies / Prognostic_studies Idioma: En Ano de publicação: 2024 Tipo de documento: Article

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