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Long COVID manifests with T cell dysregulation, inflammation and an uncoordinated adaptive immune response to SARS-CoV-2.
Yin, Kailin; Peluso, Michael J; Luo, Xiaoyu; Thomas, Reuben; Shin, Min-Gyoung; Neidleman, Jason; Andrew, Alicer; Young, Kyrlia C; Ma, Tongcui; Hoh, Rebecca; Anglin, Khamal; Huang, Beatrice; Argueta, Urania; Lopez, Monica; Valdivieso, Daisy; Asare, Kofi; Deveau, Tyler-Marie; Munter, Sadie E; Ibrahim, Rania; Ständker, Ludger; Lu, Scott; Goldberg, Sarah A; Lee, Sulggi A; Lynch, Kara L; Kelly, J Daniel; Martin, Jeffrey N; Münch, Jan; Deeks, Steven G; Henrich, Timothy J; Roan, Nadia R.
Afiliação
  • Yin K; Gladstone Institutes, University of California, San Francisco, San Francisco, CA, USA.
  • Peluso MJ; Department of Urology, University of California, San Francisco, San Francisco, CA, USA.
  • Luo X; Division of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, San Francisco, CA, USA.
  • Thomas R; Gladstone Institutes, University of California, San Francisco, San Francisco, CA, USA.
  • Shin MG; Department of Urology, University of California, San Francisco, San Francisco, CA, USA.
  • Neidleman J; Gladstone Institutes, University of California, San Francisco, San Francisco, CA, USA.
  • Andrew A; Gladstone Institutes, University of California, San Francisco, San Francisco, CA, USA.
  • Young KC; Gladstone Institutes, University of California, San Francisco, San Francisco, CA, USA.
  • Ma T; Department of Urology, University of California, San Francisco, San Francisco, CA, USA.
  • Hoh R; Gladstone Institutes, University of California, San Francisco, San Francisco, CA, USA.
  • Anglin K; Department of Urology, University of California, San Francisco, San Francisco, CA, USA.
  • Huang B; Gladstone Institutes, University of California, San Francisco, San Francisco, CA, USA.
  • Argueta U; Department of Urology, University of California, San Francisco, San Francisco, CA, USA.
  • Lopez M; Gladstone Institutes, University of California, San Francisco, San Francisco, CA, USA.
  • Valdivieso D; Department of Urology, University of California, San Francisco, San Francisco, CA, USA.
  • Asare K; Division of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, San Francisco, CA, USA.
  • Deveau TM; Division of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, San Francisco, CA, USA.
  • Munter SE; Division of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, San Francisco, CA, USA.
  • Ibrahim R; Division of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, San Francisco, CA, USA.
  • Ständker L; Division of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, San Francisco, CA, USA.
  • Lu S; Division of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, San Francisco, CA, USA.
  • Goldberg SA; Division of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, San Francisco, CA, USA.
  • Lee SA; Division of Experimental Medicine, University of California, San Francisco, San Francisco, CA, USA.
  • Lynch KL; Division of Experimental Medicine, University of California, San Francisco, San Francisco, CA, USA.
  • Kelly JD; Division of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, San Francisco, CA, USA.
  • Martin JN; Core Facility Functional Peptidomics, Ulm University Medical Center, Ulm, Germany.
  • Münch J; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA.
  • Deeks SG; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA.
  • Henrich TJ; Zuckerberg San Francisco General Hospital and the University of California, San Francisco, San Francisco, CA, USA.
  • Roan NR; Division of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.
Nat Immunol ; 25(2): 218-225, 2024 Feb.
Article em En | MEDLINE | ID: mdl-38212464
ABSTRACT
Long COVID (LC) occurs after at least 10% of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, yet its etiology remains poorly understood. We used 'omic" assays and serology to deeply characterize the global and SARS-CoV-2-specific immunity in the blood of individuals with clear LC and non-LC clinical trajectories, 8 months postinfection. We found that LC individuals exhibited systemic inflammation and immune dysregulation. This was evidenced by global differences in T cell subset distribution implying ongoing immune responses, as well as by sex-specific perturbations in cytolytic subsets. LC individuals displayed increased frequencies of CD4+ T cells poised to migrate to inflamed tissues and exhausted SARS-CoV-2-specific CD8+ T cells, higher levels of SARS-CoV-2 antibodies and a mis-coordination between their SARS-CoV-2-specific T and B cell responses. Our analysis suggested an improper crosstalk between the cellular and humoral adaptive immunity in LC, which can lead to immune dysregulation, inflammation and clinical symptoms associated with this debilitating condition.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: SARS-CoV-2 / COVID-19 Limite: Female / Humans / Male Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: SARS-CoV-2 / COVID-19 Limite: Female / Humans / Male Idioma: En Ano de publicação: 2024 Tipo de documento: Article