Correlation between serum biomarkers, brain volume, and retinal neuronal loss in early-onset Alzheimer's disease.
Neurol Sci
; 45(6): 2615-2623, 2024 Jun.
Article
em En
| MEDLINE
| ID: mdl-38216851
ABSTRACT
PURPOSE:
To compare the peripapillary retinal nerve fiber layer (pRNFL), retinal nerve fiber layer (RNFL), and ganglion cell complex (GCC) thickness measurement in early-onset Alzheimer's disease (EOAD) and controls using spectral domain optical coherence tomography (SD-OCT). We also assessed the relationship between SD-OCT measurements and cognitive measures, serum biomarkers for Alzheimer's disease (AD), and cerebral microstructural volume.METHODS:
pRNFL, RNFL, and GCC thicknesses were measured in 43 EOAD and 42 controls using SD-OCT. Montreal Cognitive Assessment (MoCA) and Mini-Mental State Examination (MMSE) were used to assess cognitive status, magnetic resonance imaging (MRI) tool was used to quantify cerebral microstructural volume, and serum biomarkers were quantified from peripheral blood.RESULTS:
EOAD patients had thinner pRNFL (P < 0.001), RNFL (P = 0.008), and GCC (P = 0.018) thicknesses compared to controls after adjusting for multiple factors. pRNFL thickness correlated (P = 0.016) with serum t-tau level. Serum Aß42 (P < 0.05) concentration correlated with RNFL thickness. Importantly, occipital lobe volume (P = 0.010) correlated with GCC thicknesses in EOAD patients.CONCLUSION:
Our findings suggest that retinal thickness may be useful markers for assessing neurodegenerative process in EOAD.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Encéfalo
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Biomarcadores
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Tomografia de Coerência Óptica
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Doença de Alzheimer
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article