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Maternal and paternal risk factors for fetal alcohol spectrum disorders: Alcohol and other drug use as proximal influences.
May, Philip A; Hasken, Julie M; de Vries, Marlene M; Marais, Anna-Susan; Abdul-Rahman, Omar; Robinson, Luther K; Adam, Margaret P; Manning, Melanie A; Kalberg, Wendy O; Buckley, David; Seedat, Soraya; Parry, Charles D H; Hoyme, H Eugene.
Afiliação
  • May PA; Nutrition Research Institute, The University of North Carolina at Chapel Hill, Kannapolis, North Carolina, USA.
  • Hasken JM; Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
  • de Vries MM; Center on Alcoholism, Substance Abuse and Addictions, The University of New Mexico, Albuquerque, New Mexico, USA.
  • Marais AS; Nutrition Research Institute, The University of North Carolina at Chapel Hill, Kannapolis, North Carolina, USA.
  • Abdul-Rahman O; Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
  • Robinson LK; Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
  • Adam MP; Department of Pediatrics, New York- Presbyterian Weill Cornell Medicine, Columbia University, New York, New York, USA.
  • Manning MA; Department of Pediatrics, State University of New York, Buffalo, New York, USA.
  • Kalberg WO; Department of Pediatrics, University of Washington, Seattle, Washington, USA.
  • Buckley D; Department of Pathology and Pediatrics, Stanford University School of Medicine, Stanford, California, USA.
  • Seedat S; Center on Alcoholism, Substance Abuse and Addictions, The University of New Mexico, Albuquerque, New Mexico, USA.
  • Parry CDH; Center on Alcoholism, Substance Abuse and Addictions, The University of New Mexico, Albuquerque, New Mexico, USA.
  • Hoyme HE; Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Alcohol Clin Exp Res (Hoboken) ; 47(11): 2090-2109, 2023 Nov.
Article em En | MEDLINE | ID: mdl-38226752
ABSTRACT

OBJECTIVE:

To explore and analyze the significance of proximal influences of maternal and paternal traits associated with bearing a child with a fetal alcohol spectrum disorder (FASD).

METHODS:

Aggregated, maternal interview-collected data (N = 2515) concerning alcohol, tobacco, and other drug use were examined to determine risk for FASD from seven cross-sectional samples of mothers of first-grade students who were evaluated for a possible diagnosis of FASD.

RESULTS:

Mothers of children with fetal alcohol syndrome (FAS) reported the highest alcohol use throughout pregnancy, proportion of binge drinking, drinks per drinking day (DDD), drinking days per week, and total drinks per week. Mothers of children with FAS also consumed significantly more alcohol than mothers of children with partial FAS (PFAS), alcohol-related neurodevelopmental disorder (ARND), or typically developing controls. Mothers of children with PFAS and ARND reported similar drinking patterns, which exposed fetuses to 3-4 times more alcohol than mothers of controls, but the PFAS group was more likely than the ARND group to abstain in latter trimesters. Fathers of all children were predominantly drinkers (70%-85%), but more fathers of children with FASD binged heavily on more days than fathers of controls. Compared to the few mothers of controls who used alcohol during pregnancy, the ARND group binge drank more (3+ DDD) throughout pregnancy and drank more DDD before pregnancy and first trimester. Regression analysis, controlling for tobacco use, indicated that mothers who reported drinking <1 DDD were significantly more likely than abstainers to bear a child with FASD (OR = 2.75) as were those reporting higher levels such as 5-5.9 DDD (OR = 32.99). Exclusive, first-trimester maternal drinking increased risk for FASD five times over that of abstinence (p < 0.001, OR = 5.05, 95% CI 3.88-6.58), first- and second-trimester drinking by 12.4 times, and drinking all trimesters by 16 times (p < 0.001, OR = 15.69, 95% CI 11.92-20.64). Paternal drinking during and prior to pregnancy, without adjustment, increased the likelihood of FASD significantly (OR = 1.06 and 1.11, respectively), but the significance of both relationships disappeared when maternal alcohol and tobacco use were controlled.

CONCLUSIONS:

Differences in FASD risk emerged from the examination of multiple proximal variables of maternal alcohol and tobacco use, reflecting increased FASD risk at greater levels of maternal alcohol consumption.
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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Etiology_studies / Risk_factors_studies Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Etiology_studies / Risk_factors_studies Idioma: En Ano de publicação: 2023 Tipo de documento: Article