Implications of stress-induced gene expression for hematopoietic stem cell aging studies.
Nat Aging
; 4(2): 177-184, 2024 Feb.
Article
em En
| MEDLINE
| ID: mdl-38228925
ABSTRACT
A decline in hematopoietic stem cell (HSC) function is believed to underlie hematological shortcomings with age; however, a comprehensive molecular understanding of these changes is currently lacking. Here we provide evidence that a transcriptional signature reported in several previous studies on HSC aging is linked to stress-induced changes in gene expression rather than aging. Our findings have strong implications for the design and interpretation of HSC aging studies.
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1
Base de dados:
MEDLINE
Assunto principal:
Células-Tronco Hematopoéticas
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article