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The effect of dairy products on liver fat and metabolic risk markers in males with abdominal obesity - a four-arm randomized controlled trial.
Sandby, Karoline; Magkos, Faidon; Chabanova, Elizaveta; Petersen, Esben T; Krarup, Thure; Bertram, Hanne C; Kristiansen, Karsten; Geiker, Nina R W.
Afiliação
  • Sandby K; Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark. Electronic address: ksa@nexs.ku.dk.
  • Magkos F; Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark.
  • Chabanova E; Department of Radiology, Copenhagen University Hospital Herlev Gentofte, Denmark.
  • Petersen ET; Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Amager and Hvidovre, Denmark; Section for Magnetic Resonance, Department of Health Technology, Technical University of Denmark, Denmark.
  • Krarup T; Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark; Department of Endocrinology, Copenhagen University Hospital Bispebjerg and Frederiksberg, Denmark.
  • Bertram HC; Department of Food Science, Aarhus University, Denmark.
  • Kristiansen K; Laboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, Denmark; Institute of Metagenomics, Qingdao-Europe Advanced Institute for Life Sciences, Denmark.
  • Geiker NRW; Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark; Center for Childhood Health, Denmark.
Clin Nutr ; 43(2): 534-542, 2024 02.
Article em En | MEDLINE | ID: mdl-38232682
ABSTRACT
BACKGROUND &

AIMS:

In recent years, epidemiological studies have reported links between the consumption of fermented dairy products, such as yogurt, and health; however, evidence from human intervention trials is scarce and inconsistent. We aimed to investigate the effect of consumption of four different types of dairy products (two fermented and two non-fermented) on liver fat (primary outcome) and metabolic risk markers in males with abdominal obesity.

METHODS:

In this parallel randomized controlled trial with four arms, 100 males aged 30-70 years, with body mass index 28.0-45.0 kg/m2, and waist circumference ≥102 cm underwent a 16-weeks intervention where they were instructed to consume 400 g/day of either milk, yogurt, heat-treated yogurt, or acidified milk as part of their habitual diet. Liver fat was measured by magnetic resonance imaging.

RESULTS:

In the complete case analyses (n = 80), no effects of the intervention or differences between groups were detected in anthropometry or body composition including liver fat. Moreover, no effects were detected in inflammatory markers. Main effects of time were detected in blood pressure (decrease; P < 0.001), insulin (decrease; P < 0.001), C-peptide (decrease; P = 0.040), homeostatic model assessment for insulin resistance (decrease; P < 0.001), total cholesterol (decrease; P = 0.016), low-density lipoprotein (decrease; P = 0.033), high-density lipoprotein (decrease; P = 0.006), and alanine transaminase (decrease; P = 0.019). Interactions between group and time failed to reach significance.

CONCLUSIONS:

In conclusion, findings from our study do not confirm that fermented yogurt products are superior in reducing liver fat or improving metabolic risk markers compared to non-fermented milk products. In fact, all intervention products (both fermented yogurt products and non-fermented milk products) did not affect liver fat and caused largely similar modest favorable changes in some metabolic risk markers. The study was registered at www. CLINICALTRIALS gov (# NCT04755530).
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Produtos Fermentados do Leite / Obesidade Abdominal Tipo de estudo: Clinical_trials / Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Produtos Fermentados do Leite / Obesidade Abdominal Tipo de estudo: Clinical_trials / Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2024 Tipo de documento: Article