Function and mechanism of TREM2 in bacterial infection.
PLoS Pathog
; 20(1): e1011895, 2024 Jan.
Article
em En
| MEDLINE
| ID: mdl-38236825
ABSTRACT
Triggering receptor expressed on myeloid cells 2 (TREM2), which is a lipid sensing and phagocytosis receptor, plays a key role in immunity and inflammation in response to pathogens. Here, we review the function and signaling of TREM2 in microbial binding, engulfment and removal, and describe TREM2-mediated inhibition of inflammation by negatively regulating the Toll-like receptor (TLR) response. We further illustrate the role of TREM2 in restoring organ homeostasis in sepsis and soluble TREM2 (sTREM2) as a diagnostic marker for sepsis-associated encephalopathy (SAE). Finally, we discuss the prospect of TREM2 as an interesting therapeutic target for sepsis.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Infecções Bacterianas
/
Sepse
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article