Targeting 'histone mark': Advanced approaches in epigenetic regulation of telomere dynamics in cancer.
Biochim Biophys Acta Gene Regul Mech
; 1867(1): 195007, 2024 Mar.
Article
em En
| MEDLINE
| ID: mdl-38237857
ABSTRACT
Telomere integrity is required for the maintenance of genome stability and prevention of oncogenic transformation of cells. Recent evidence suggests the presence of epigenetic modifications as an important regulator of mammalian telomeres. Telomeric and subtelomeric regions are rich in epigenetic marks that regulate telomere length majorly through DNA methylation and post-translational histone modifications. Specific histone modifying enzymes play an integral role in establishing telomeric histone codes necessary for the maintenance of structural integrity. Alterations of crucial histone moieties and histone modifiers cause deregulations in the telomeric chromatin leading to carcinogenic manifestations. This review delves into the significance of histone modifications and their influence on telomere dynamics concerning cancer. Additionally, it highlights the existing research gaps that hold the potential to drive the development of therapeutic interventions targeting the telomere epigenome.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Histonas
/
Epigênese Genética
Limite:
Animals
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article