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Traceless Peptide and Protein Modification via Rational Tuning of Pyridiniums.
Wan, Chuan; Zhang, Yichi; Wang, Jinpeng; Xing, Yun; Yang, Dongyan; Luo, Qinhong; Liu, Jianbo; Ye, Yuxin; Liu, Zhihong; Yin, Feng; Wang, Rui; Li, Zigang.
Afiliação
  • Wan C; State Key Laboratory of Chemical Oncogenomics, Guangdong Provincial Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen 518055, China.
  • Zhang Y; College of Health Science and Environmental Engineering, Shenzhen Technology University, Shenzhen 518118, China.
  • Wang J; State Key Laboratory of Chemical Oncogenomics, Guangdong Provincial Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen 518055, China.
  • Xing Y; State Key Laboratory of Chemical Oncogenomics, Guangdong Provincial Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen 518055, China.
  • Yang D; Pingshan Translational Medicine Center, Shenzhen Bay Laboratory, Shenzhen 518118, China.
  • Luo Q; College of Chemistry and Chemical Engineering, Zhongkai University of Agriculture and Engineering, Guangzhou 510230, China.
  • Liu J; State Key Laboratory of Chemical Oncogenomics, Guangdong Provincial Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen 518055, China.
  • Ye Y; Pingshan Translational Medicine Center, Shenzhen Bay Laboratory, Shenzhen 518118, China.
  • Liu Z; Pingshan Translational Medicine Center, Shenzhen Bay Laboratory, Shenzhen 518118, China.
  • Yin F; Pingshan Translational Medicine Center, Shenzhen Bay Laboratory, Shenzhen 518118, China.
  • Wang R; Pingshan Translational Medicine Center, Shenzhen Bay Laboratory, Shenzhen 518118, China.
  • Li Z; Pingshan Translational Medicine Center, Shenzhen Bay Laboratory, Shenzhen 518118, China.
J Am Chem Soc ; 146(4): 2624-2633, 2024 01 31.
Article em En | MEDLINE | ID: mdl-38239111
ABSTRACT
Herein, we report a versatile reaction platform for tracelessly cleavable cysteine-selective peptide/protein modification. This platform offers highly tunable and predictable conjugation and cleavage by rationally estimating the electron effect on the nucleophilic halopyridiniums. Cleavable peptide stapling, antibody conjugation, enzyme masking/de-masking, and proteome labeling were achieved based on this facile pyridinium-thiol-exchange protocol.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peptídeos / Proteoma Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peptídeos / Proteoma Idioma: En Ano de publicação: 2024 Tipo de documento: Article