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Elevated 18F-FDG uptake in subcutaneous adipose tissue correlates negatively with nutritional status and prognostic survival in cachexia patients with gastric cancer.
Sun, Diya; Yin, Hongyan; Liu, Xiao; Ding, Zuoyou; Shen, Lei; Sah, Szechun; Han, Jun; Wu, Guohao.
Afiliação
  • Sun D; Department of General Surgery, Zhongshan Hospital of Fudan University, Shanghai, China.
  • Yin H; Department of Nuclear Medicine, Zhongshan Hospital of Fudan University, Shanghai, China.
  • Liu X; Department of Nursing, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Ding Z; Department of General Surgery, Zhongshan Hospital of Fudan University, Shanghai, China.
  • Shen L; Department of General Surgery, Zhongshan Hospital of Fudan University, Shanghai, China.
  • Sah S; Department of General Surgery, Zhongshan Hospital of Fudan University, Shanghai, China.
  • Han J; Department of General Surgery, Zhongshan Hospital of Fudan University, Shanghai, China; Shanghai Clinical Nutrition Research Centre, Shanghai, China. Electronic address: hanjun198626@163.com.
  • Wu G; Department of General Surgery, Zhongshan Hospital of Fudan University, Shanghai, China; Shanghai Clinical Nutrition Research Centre, Shanghai, China. Electronic address: profwugh@163.com.
Clin Nutr ; 43(2): 567-574, 2024 02.
Article em En | MEDLINE | ID: mdl-38242034
ABSTRACT

BACKGROUND:

Browning of white adipose tissue is a crucial factor contributing to adipose loss in cachexia patients, detectable via 18F-Fluorodeoxyglucose (18F-FDG) uptake. The present study elucidates the clinical relevance of 18F-FDG uptake in the subcutaneous adipose tissue of gastric cancer patients, specifically focusing on adipose browning and its implications on patient clinical parameters and prognosis.

METHODS:

This investigation encompassed 770 gastric cancer patients, with PET-CT imaging and clinical data meticulously combined. The 18F-FDG uptake in subcutaneous adipose tissue at the third lumbar layer was quantified, and its correlation with clinical parameters, particularly those related to nutritional status and fat metabolism, was examined. Kaplan-Meier curves were subsequently employed to probe the relationship between 18F-FDG uptake and overall survival.

RESULTS:

Of the 770 gastric cancer patients, 252 exhibited cancer-associated cachexia, while 518 did not. Cachectic patients demonstrated elevated 18F-FDG uptake in subcutaneous adipose tissue relative to non-cachectic patients (P < 0.001). Increased 18F-FDG uptake was also correlated with reduced plasma concentrations of albumin, prealbumin, hemoglobin, platelets, cholesterol, apolipoprotein A, low-density lipoprotein, and elevated IL-6 concentrations (all P < 0.05). A significant inverse correlation was observed between 18F-FDG uptake and BMI, albumin, low-density lipoprotein, cholesterol, and apolipoprotein A (all P < 0.05). Patients with higher 18F-FDG uptake exhibited diminished overall survival rates compared to those with lower 18F-FDG uptake (P = 0.0065). Furthermore, 18F-FDG uptake in subcutaneous adipose tissue was an independent prognostic indicator in gastric cancer patients (P = 0.028).

CONCLUSIONS:

Browning of subcutaneous adipose tissue was markedly elevated in cachectic gastric cancer patients compared to non-cachectic counterparts. Increased 18F-FDG uptake in subcutaneous adipose tissue in cachectic gastric cancer patients was inversely correlated with nutritional status and survival prognosis.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Gástricas / Fluordesoxiglucose F18 Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Gástricas / Fluordesoxiglucose F18 Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article