An Overview of Different Vitamin D Compounds in the Setting of Adiposity.
Nutrients
; 16(2)2024 Jan 11.
Article
em En
| MEDLINE
| ID: mdl-38257127
ABSTRACT
A large body of research shows an association between higher body weight and low vitamin D status, as assessed using serum 25-hydroxyvitamin D concentrations. Vitamin D can be metabolised in adipose tissue and has been reported to influence gene expression and modulate inflammation and adipose tissue metabolism in vitro. However, the exact metabolism of vitamin D in adipose tissue is currently unknown. White adipose tissue expresses the vitamin D receptor and hydroxylase enzymes, substantially involved in vitamin D metabolism and efficacy. The distribution and concentrations of the generated vitamin D compounds in adipose tissue, however, are largely unknown. Closing this knowledge gap could help to understand whether the different vitamin D compounds have specific health effects in the setting of adiposity. This review summarises the current evidence for a role of vitamin D in adipose tissue and discusses options to accurately measure vitamin D compounds in adipose tissue using liquid chromatography tandem mass spectrometry (LC/MS-MS).
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Adiposidade
/
Obesidade
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article