Emerging Pathophysiological Roles of Ketone Bodies.
Physiology (Bethesda)
; 39(3): 0, 2024 May 01.
Article
em En
| MEDLINE
| ID: mdl-38260943
ABSTRACT
The discovery of insulin approximately a century ago greatly improved the management of diabetes, including many of its life-threatening acute complications like ketoacidosis. This breakthrough saved many lives and extended the healthy lifespan of many patients with diabetes. However, there is still a negative perception of ketone bodies stemming from ketoacidosis. Originally, ketone bodies were thought of as a vital source of energy during fasting and exercise. Furthermore, in recent years, research on calorie restriction and its potential impact on extending healthy lifespans, as well as studies on ketone bodies, have gradually led to a reevaluation of the significance of ketone bodies in promoting longevity. Thus, in this review, we discuss the emerging and hidden roles of ketone bodies in various organs, including the heart, kidneys, skeletal muscles, and brain, as well as their potential impact on malignancies and lifespan.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Diabetes Mellitus
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Cetose
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article