Mosquitoes provide a transmission route between possums and humans for Buruli ulcer in southeastern Australia.
Nat Microbiol
; 9(2): 377-389, 2024 Feb.
Article
em En
| MEDLINE
| ID: mdl-38263454
ABSTRACT
Buruli ulcer, a chronic subcutaneous infection caused by Mycobacterium ulcerans, is increasing in prevalence in southeastern Australia. Possums are a local wildlife reservoir for M. ulcerans and, although mosquitoes have been implicated in transmission, it remains unclear how humans acquire infection. We conducted extensive field survey analyses of M. ulcerans prevalence among mosquitoes in the Mornington Peninsula region of southeastern Australia. PCR screening of trapped mosquitoes revealed a significant association between M. ulcerans and Aedes notoscriptus. Spatial scanning statistics revealed overlap between clusters of M. ulcerans-positive Ae. notoscriptus, M. ulcerans-positive possum excreta and Buruli ulcer cases, and metabarcoding analyses showed individual mosquitoes had fed on humans and possums. Bacterial genomic analysis confirmed shared single-nucleotide-polymorphism profiles for M. ulcerans detected in mosquitoes, possum excreta and humans. These findings indicate Ae. notoscriptus probably transmit M. ulcerans in southeastern Australia and highlight mosquito control as a Buruli ulcer prevention measure.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Mycobacterium ulcerans
/
Aedes
/
Úlcera de Buruli
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
/
Humans
País como assunto:
Oceania
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article