Protocol for establishing a global ischemia model using a 4-vessel occlusion in rats.
STAR Protoc
; 4(4): 102630, 2023 Dec 15.
Article
em En
| MEDLINE
| ID: mdl-38264871
ABSTRACT
Global cerebral ischemia occurs when blood flow to the entire brain is transiently blocked, which results in delayed neurologic deficits. Here, we present a protocol for performing the four-vessel occlusion rat model to study the neurodegeneration and cognitive deficits associated with global ischemia. We describe steps for carrying out the vertebral and common carotid artery occlusion which enables sufficient blockage of cerebral blood flow. We then detail expected outcomes using histology assays and behavioral tests. For complete details on the use and execution of this protocol, please refer to Chung et al. (2022).1.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Transtornos Cognitivos
/
Isquemia
Limite:
Animals
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article