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Ubrogepant: Mechanism of action, clinical and translational science.
Boinpally, Ramesh; Shebley, Mohamad; Trugman, Joel.
Afiliação
  • Boinpally R; Clinical Pharmacology, AbbVie, North Chicago, Illinois, USA.
  • Shebley M; Clinical Pharmacology, AbbVie, North Chicago, Illinois, USA.
  • Trugman J; Clinical Development, AbbVie, North Chicago, Illinois, USA.
Clin Transl Sci ; 17(1): e13675, 2024 01.
Article em En | MEDLINE | ID: mdl-38266060
ABSTRACT
In recent years, the treatment of migraine has experienced a breakthrough in the development of drugs that target the calcitonin gene-related peptide (CGRP) signaling pathway. Monoclonal antibodies against the receptor or ligand have been developed for the preventive treatment of migraine; whereas, orally administered small molecule CGRP receptor antagonists, called gepants, have been developed for both acute and/or preventive treatment. Both modalities have demonstrated safe and effective treatment of migraine, reducing the number of migraine days for patients as well as reducing symptoms and improving patient function and overall quality of life. Here, we provide an abridged review of ubrogepant, an oral CGRP receptor antagonist, approved for the acute treatment of migraine. We briefly summarize the role of CGRP in migraine pathophysiology, describing the mechanism of action of ubrogepant in the context of this pathway, the clinical pharmacology properties and the clinical development and outcomes, including safety, efficacy, pharmacokinetics, and pharmacodynamics, that supported ubrogepant's approval.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piridinas / Pirróis / Ciência Translacional Biomédica / Transtornos de Enxaqueca Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piridinas / Pirróis / Ciência Translacional Biomédica / Transtornos de Enxaqueca Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article