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MicroCycle: An Integrated and Automated Platform to Accelerate Drug Discovery.
Brocklehurst, Cara E; Altmann, Eva; Bon, Corentin; Davis, Holly; Dunstan, David; Ertl, Peter; Ginsburg-Moraff, Carol; Grob, Jonathan; Gosling, Daniel J; Lapointe, Guillaume; Marziale, Alexander N; Mues, Heinrich; Palmieri, Marco; Racine, Sophie; Robinson, Richard I; Springer, Clayton; Tan, Kian; Ulmer, William; Wyler, René.
Afiliação
  • Brocklehurst CE; Global Discovery Chemistry, Novartis Biomedical Research, Novartis Pharma AG, Basel 4033, Switzerland.
  • Altmann E; Global Discovery Chemistry, Novartis Biomedical Research, Novartis Pharma AG, Basel 4033, Switzerland.
  • Bon C; Global Discovery Chemistry, Novartis Biomedical Research, Novartis Pharma AG, Basel 4033, Switzerland.
  • Davis H; Global Discovery Chemistry, Novartis Biomedical Research, Novartis Pharma AG, Basel 4033, Switzerland.
  • Dunstan D; Global Discovery Chemistry, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States.
  • Ertl P; Global Discovery Chemistry, Novartis Biomedical Research, Novartis Pharma AG, Basel 4033, Switzerland.
  • Ginsburg-Moraff C; Global Discovery Chemistry, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States.
  • Grob J; Global Discovery Chemistry, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States.
  • Gosling DJ; Global Discovery Chemistry, Novartis Biomedical Research, Novartis Pharma AG, Basel 4033, Switzerland.
  • Lapointe G; Global Discovery Chemistry, Novartis Biomedical Research, Novartis Pharma AG, Basel 4033, Switzerland.
  • Marziale AN; Global Discovery Chemistry, Novartis Biomedical Research, Novartis Pharma AG, Basel 4033, Switzerland.
  • Mues H; Global Discovery Chemistry, Novartis Biomedical Research, Novartis Pharma AG, Basel 4033, Switzerland.
  • Palmieri M; Global Discovery Chemistry, Novartis Biomedical Research, Novartis Pharma AG, Basel 4033, Switzerland.
  • Racine S; Global Discovery Chemistry, Novartis Biomedical Research, Novartis Pharma AG, Basel 4033, Switzerland.
  • Robinson RI; Global Discovery Chemistry, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States.
  • Springer C; Global Discovery Chemistry, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States.
  • Tan K; Global Discovery Chemistry, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States.
  • Ulmer W; Global Discovery Chemistry, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States.
  • Wyler R; Global Discovery Chemistry, Novartis Biomedical Research, Novartis Pharma AG, Basel 4033, Switzerland.
J Med Chem ; 67(3): 2118-2128, 2024 02 08.
Article em En | MEDLINE | ID: mdl-38270627
ABSTRACT
We herein describe the development and application of a modular technology platform which incorporates recent advances in plate-based microscale chemistry, automated purification, in situ quantification, and robotic liquid handling to enable rapid access to high-quality chemical matter already formatted for assays. In using microscale chemistry and thus consuming minimal chemical matter, the platform is not only efficient but also follows green chemistry principles. By reorienting existing high-throughput assay technology, the platform can generate a full package of relevant data on each set of compounds in every learning cycle. The multiparameter exploration of chemical and property space is hereby driven by active learning models. The enhanced compound optimization process is generating knowledge for drug discovery projects in a time frame never before possible.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Descoberta de Drogas / Ensaios de Triagem em Larga Escala Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Descoberta de Drogas / Ensaios de Triagem em Larga Escala Idioma: En Ano de publicação: 2024 Tipo de documento: Article