Phosphatidylserine turns the gears of phospholipids in B cell lymphoma.

Nakatsu, Fubito; Kawasaki, Asami

Nakatsu, Fubito; Kawasaki, Asami.

Afiliação

Nakatsu F; Department of Neurochemistry and Molecular Cell Biology, Niigata University School of Medicine and Graduate School of Medical/Dental Sciences, Niigata, Japan.
Kawasaki A; Department of Neurochemistry and Molecular Cell Biology, Niigata University School of Medicine and Graduate School of Medical/Dental Sciences, Niigata, Japan.

J Cell Biol ; 223(2)2024 02 05.

Article em En | MEDLINE | ID: mdl-38270920

ABSTRACT

ABSTRACT

Phosphatidylserine levels and distribution are tightly controlled by dedicated enzymes at the ER and plasma membrane. Nakatsu and Kawasaki discuss new work by Aoki and colleagues (https//doi.org/10.1083/jcb.202212074), which reveals an acute reliance on phosphatidylserine synthesis in B cell lymphomas needed to prevent aberrant B cell receptor activation and ensuing apoptosis.

Assuntos

Linfoma de Células B; Fosfatidilserinas; Receptores de Antígenos de Linfócitos B; Humanos; Apoptose; Linfoma de Células B/metabolismo; Fosfatidilserinas/metabolismo; Fosfolipídeos/metabolismo; Estrutura Secundária de Proteína; Receptores de Antígenos de Linfócitos B/metabolismo

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fosfatidilserinas / Receptores de Antígenos de Linfócitos B / Linfoma de Células B Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google