Indirect CD4+ T cell protection against persistent MCMV infection by NK cells requires IFNγ.
J Gen Virol
; 105(1)2024 01.
Article
em En
| MEDLINE
| ID: mdl-38271001
ABSTRACT
Host control of mouse cytomegalovirus (MCMV) infection of MHCII- salivary gland acinar cells is mediated by CD4+ T cells, but how they protect is unclear. Here, we show CD4+ T cells control MCMV indirectly in the salivary gland, via IFNγ engagement with uninfected, but antigen+ MHCII+ APC and recruitment of NK cells to infected cell foci. This immune mechanism renders direct contact of CD4+ T cells with infected cells unnecessary and may represent a host strategy to overcome viral immune evasion.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Muromegalovirus
/
Infecções por Citomegalovirus
Limite:
Animals
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article