Fisetin suppresses chondrocyte senescence and attenuates osteoarthritis progression by targeting sirtuin 6.

Wang, Xuezhong; Li, Xuyang; Zhou, Jianlin; Lei, Zheng; Yang, Xiaoming

Wang, Xuezhong; Li, Xuyang; Zhou, Jianlin; Lei, Zheng; Yang, Xiaoming.

Afiliação

Wang X; Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Li X; Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Zhou J; Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Lei Z; Department of Emergency Medicine, China-Japan Union Hospital of Jilin University, Changchun, 130033, China.
Yang X; Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, 430060, China. Electronic address: yangxm6@whu.edu.cn.

Chem Biol Interact ; 390: 110890, 2024 Feb 25.

Article em En | MEDLINE | ID: mdl-38278314

Assuntos

Cartilagem Articular; Osteoartrite; Sirtuínas; Humanos; Ratos; Animais; Idoso; Condrócitos; Osteoartrite/tratamento farmacológico; Osteoartrite/patologia; Flavonóis/farmacologia; Flavonóis/metabolismo; Interleucina-1beta/metabolismo; Cartilagem Articular/metabolismo; Sirtuínas/metabolismo; Senescência Celular

Palavras-chave

Anti-Senescent; Cartilage; Fisetin; Osteoarthritis; Sirtuin 6

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Osteoartrite / Cartilagem Articular / Sirtuínas Limite: Aged / Animals / Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article

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