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Multifunctional self-healing peptide hydrogel for wound healing.
Jin, Jiman; Sun, Chuchu; Xu, Keyuan; Sun, Xiaoliang; Cao, Lingling; Liu, Liangle.
Afiliação
  • Jin J; The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou 325200, China.
  • Sun C; The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou 325200, China.
  • Xu K; The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou 325200, China.
  • Sun X; The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou 325200, China.
  • Cao L; Jiujiang City Key Laboratory of Cell Therapy, The First Hospital of Jiujiang City, Jiujiang 332000, China. Electronic address: 1309316573@qq.com.
  • Liu L; The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou 325200, China. Electronic address: liuliangle@wmu.edu.cn.
Int J Biol Macromol ; 261(Pt 1): 129734, 2024 Mar.
Article em En | MEDLINE | ID: mdl-38281530
ABSTRACT
The complete healing of wounds remains a challenge in clinical care. In addition, various complications such as inflammation and infection that may occur during skin wound healing can impede the healing process. Here, we constructed a multifunctional self-repairing hydrogel by utilizing Schiff base bonds. This hydrogel exhibited good self-healing properties and could cope with destructive external influences. The self-healing hydrogel was injectable, ensuring that the hydrogel dressing adhered to the wound. Carboxymethyl chitosan and oxidized chondroitin sulfate demonstrated good biocompatibility and multiple bioactivities and were successfully used to prepare self-healing hydrogels. Meanwhile, the SIKVAV biopeptide was less expensive and more morphologically stable than vascular endothelial growth factor and had a high pro-angiogenic activity. Thus, the SIKVAV biopeptide was cross-linked to the oxidized chondroitin sulfate of the hydrogel through covalent bonding to avoid rapid biopeptide degradation, achieving a slow release of the drug. This peptide hydrogel exhibited good biocompatibility and antimicrobial properties; moreover, experiments conducted on mice revealed that it could effectively promote angiogenesis and skin tissue repair. These findings suggest that the injectable self-repairing peptide hydrogel may facilitate skin wound healing and other applications.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hidrogéis / Quitosana Limite: Animals Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hidrogéis / Quitosana Limite: Animals Idioma: En Ano de publicação: 2024 Tipo de documento: Article