Visible-light-induced synthesis of 2,4-disubstituted quinolines from o-vinylaryl isocyanides and oxime esters.
Org Biomol Chem
; 22(7): 1458-1465, 2024 Feb 14.
Article
em En
| MEDLINE
| ID: mdl-38282546
ABSTRACT
A visible-light-induced radical cyclization reaction of o-vinylaryl isocyanides and oxime esters to access various 2,4-disubstituted quinolines was disclosed. Oxime esters were employed as acyl radical precursors via the carbon-carbon bond cleavage. It provided an effective way for the synthesis of 2-acyl-4-arlysubstituted quinolines under mild conditions and exhibited good functional group tolerance and substrate applicability.
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Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2024
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Article