Exploring Hollow Mesoporous Silica Nanoparticles as a Nanocarrier in the Delivery of Foot-And-Mouth Disease Virus-like Particle Vaccines.
ACS Appl Bio Mater
; 7(2): 1064-1072, 2024 02 19.
Article
em En
| MEDLINE
| ID: mdl-38286026
ABSTRACT
Virus-like particle (VLP) vaccine is considered to be the most promising candidate alternative to the traditional inactivated vaccine for foot-and-mouth disease (FMD). To elicit a desired immune response, hollow mesoporous silica nanoparticles (HMSNs) have been synthesized and utilized as a nanocarrier for FMD VLP vaccine delivery. The as-prepared HMSNs displayed a relatively small particle size (â¼260 nm), large cavity (â¼150 nm), and thin wall (â¼55 nm). The inherent structural superiorities make them ideal nanocarriers for the FMD VLP vaccine, which exhibited good biocompatibility, great protein-loading capacity, high antibody-response level, and protective efficiency, even comparable to commercial adjuvant ISA 206. All the results suggested that HMSNs may be a valid nanocarrier in VLP-based vaccines.
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Base de dados:
MEDLINE
Assunto principal:
Vacinas
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Vírus da Febre Aftosa
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Nanopartículas
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Febre Aftosa
Limite:
Animals
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article