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Humoral profiles of toddlers and young children following SARS-CoV-2 mRNA vaccination.
Nziza, Nadège; Deng, Yixiang; Wood, Lianna; Dhanoa, Navneet; Dulit-Greenberg, Naomi; Chen, Tina; Kane, Abigail S; Swank, Zoe; Davis, Jameson P; Demokritou, Melina; Chitnis, Anagha P; Fasano, Alessio; Edlow, Andrea G; Jain, Nitya; Horwitz, Bruce H; McNamara, Ryan P; Walt, David R; Lauffenburger, Douglas A; Julg, Boris; Shreffler, Wayne G; Alter, Galit; Yonker, Lael M.
Afiliação
  • Nziza N; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.
  • Deng Y; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.
  • Wood L; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Dhanoa N; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.
  • Dulit-Greenberg N; Boston Children's Hospital, Department of Pediatric Gastroenterology, Boston, MA, USA.
  • Chen T; Massachusetts General Hospital, Department of Pediatrics, Boston, MA, USA.
  • Kane AS; Massachusetts General Hospital, Department of Pediatrics, Boston, MA, USA.
  • Swank Z; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.
  • Davis JP; Massachusetts General Hospital, Department of Pediatrics, Boston, MA, USA.
  • Demokritou M; Massachusetts General Hospital, Mucosal Immunology and Biology Research Center, Boston, MA, USA.
  • Chitnis AP; Harvard Medical School, Boston, MA, USA.
  • Fasano A; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.
  • Edlow AG; Massachusetts General Hospital, Mucosal Immunology and Biology Research Center, Boston, MA, USA.
  • Jain N; Massachusetts General Hospital, Department of Pediatrics, Boston, MA, USA.
  • Horwitz BH; Massachusetts General Hospital, Mucosal Immunology and Biology Research Center, Boston, MA, USA.
  • McNamara RP; Massachusetts General Hospital, Department of Pediatrics, Boston, MA, USA.
  • Walt DR; Massachusetts General Hospital, Mucosal Immunology and Biology Research Center, Boston, MA, USA.
  • Lauffenburger DA; Harvard Medical School, Boston, MA, USA.
  • Julg B; Harvard Medical School, Boston, MA, USA.
  • Shreffler WG; Massachusetts General Hospital, Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Boston, MA, USA.
  • Alter G; Massachusetts General Hospital, Vincent Center for Reproductive Biology, Boston, MA, USA.
  • Yonker LM; Massachusetts General Hospital, Department of Pediatrics, Boston, MA, USA.
Nat Commun ; 15(1): 905, 2024 Jan 30.
Article em En | MEDLINE | ID: mdl-38291080
ABSTRACT
Although young children generally experience mild symptoms following infection with SARS-CoV-2, severe acute and long-term complications can occur. SARS-CoV-2 mRNA vaccines elicit robust immunoglobulin profiles in children ages 5 years and older, and in adults, corresponding with substantial protection against hospitalizations and severe disease. Whether similar immune responses and humoral protection can be observed in vaccinated infants and young children, who have a developing and vulnerable immune system, remains poorly understood. To study the impact of mRNA vaccination on the humoral immunity of infant, we use a system serology approach to comprehensively profile antibody responses in a cohort of children ages 6 months to 5 years who were vaccinated with the mRNA-1273 COVID-19 vaccine (25 µg). Responses are compared with vaccinated adults (100 µg), in addition to naturally infected toddlers and young children. Despite their lower vaccine dose, vaccinated toddlers elicit a functional antibody response as strong as adults, with higher antibody-dependent phagocytosis compared to adults, without report of side effects. Moreover, mRNA vaccination is associated with a higher IgG3-dependent humoral profile against SARS-CoV-2 compared to natural infection, supporting that mRNA vaccination is effective at eliciting a robust antibody response in toddlers and young children.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: SARS-CoV-2 / COVID-19 Limite: Adult / Child, preschool / Humans / Infant Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: SARS-CoV-2 / COVID-19 Limite: Adult / Child, preschool / Humans / Infant Idioma: En Ano de publicação: 2024 Tipo de documento: Article