Stereotactic body radiation therapy (SBRT) for the treatment of primary breast cancer in patients not undergoing surgery.
Adv Med Sci
; 69(1): 29-35, 2024 Mar.
Article
em En
| MEDLINE
| ID: mdl-38306916
ABSTRACT
PURPOSE:
The purpose was to explore the role of stereotactic body radiation therapy (SBRT) in providing local control (LC) for primary breast cancer in patients unable to undergo surgery. MATERIALS/METHODS:
Between 2015 and 2019, 13 non-surgical candidates with 14 lesions were treated with SBRT for primary breast cancer. In 4 cases, SBRT was used after whole breast radiation therapy (WBRT; 40-50 Gy/20-25 fractions). SBRT dose was 30-40 âGy in 5 fractions for patients treated with SBRT alone and 25-32 âGy in 4-5 fractions for those treated with SBRT â+ âWBRT. LC and overall survival (OS) were estimated using Kaplan-Meier curves. Response was also assessed using RECIST guidelines.RESULTS:
Median follow-up was 32 (range 3.4-70.4) months. Imaging at median 2.2 (0.6-8.1) months post-SBRT showed median 43.2 â% (range 2-100 â%) decrease in the largest diameter and median 68.7 â% (range 27.9-100 â%) SUV reduction. There were 3 cases of local progression at 8.7-10.6 months. Estimated LC was 100 â% at 6 months and 71.6 â% at 12, 24 and 36 months. Estimated median OS was 100 â% at 6 months, 76.9 â% at 12 months, and 61.5 â% at 24 and 36 months. Acute toxicity (n â= â13; 92.9 â%) included grade (G)1 (n â= â8), G2 (n â= â4), and G4 (necrosis; n â= â1). Late toxicity included G2 edema (n â= â1) and G4 necrosis (n â= â2, including 1 consequential late effect). Only patients treated with SBRT â+ âWBRT experienced acute/late G4 toxicity, managed with resection or steroids.CONCLUSIONS:
SBRT to primary breast cancer resulted in good LC in non-surgical/metastatic patients. Although necrosis (n â= â2) occurred in the SBRT â+ âWBRT group, it was successfully salvaged.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
/
Radiocirurgia
Tipo de estudo:
Guideline
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
/
Middle aged
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article