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Protoilludane-Type and Related Nor-Sesquiterpenes from Phellinus hartigii and Their Anti-Hypertrophic Activities in Rat Cardiomyocytes.
Fu, Quan; Yuan, Jing; Yang, Tie-Hua; Su, Jin-Hao; Zhang, Jing-Jing; Wu, Xue-Wen; Zhang, Hong-Ye; Xiao, Wei-Lie; Zheng, Chang-Bo; Li, Xiao-Li.
Afiliação
  • Fu Q; Key Laboratory of Medicinal Chemistry for Natural Resource of Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Yunnan Research & Development Center for Natural Products, School of Chemical Science and Technology, and School of Pharmacy, State Key Laboratory for Conservat
  • Yuan J; School of Pharmaceutical Science, Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, and Yunnan Vaccine Laboratory, Kunming, Yunnan 650500, People's Republic of China.
  • Yang TH; School of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming, Yunnan 650500, People's Republic of China.
  • Su JH; Key Laboratory of Medicinal Chemistry for Natural Resource of Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Yunnan Research & Development Center for Natural Products, School of Chemical Science and Technology, and School of Pharmacy, State Key Laboratory for Conservat
  • Zhang JJ; Key Laboratory of Medicinal Chemistry for Natural Resource of Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Yunnan Research & Development Center for Natural Products, School of Chemical Science and Technology, and School of Pharmacy, State Key Laboratory for Conservat
  • Wu XW; Key Laboratory of Medicinal Chemistry for Natural Resource of Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Yunnan Research & Development Center for Natural Products, School of Chemical Science and Technology, and School of Pharmacy, State Key Laboratory for Conservat
  • Zhang HY; School of Pharmaceutical Science, Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, and Yunnan Vaccine Laboratory, Kunming, Yunnan 650500, People's Republic of China.
  • Xiao WL; Key Laboratory of Medicinal Chemistry for Natural Resource of Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Yunnan Research & Development Center for Natural Products, School of Chemical Science and Technology, and School of Pharmacy, State Key Laboratory for Conservat
  • Zheng CB; Southwest United Graduate School, Kunming 650500, People's Republic of China.
  • Li XL; School of Pharmaceutical Science, Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, and Yunnan Vaccine Laboratory, Kunming, Yunnan 650500, People's Republic of China.
J Nat Prod ; 87(2): 297-303, 2024 02 23.
Article em En | MEDLINE | ID: mdl-38308643
ABSTRACT
Three nor-sesquiterpenes, phellinharts A-C (1-3), isolated from Phellinus hartigii, exhibited unprecedented protoilludane and cerapicane-type structures. The structures of compounds 1-3 were elucidated via spectroscopic analysis, quantum chemical calculations, and X-ray diffraction. Potential biogenic pathways involving demethylation, ring cleavage, and rearrangement were proposed. Compounds 1-3 displayed potent anti-hypertrophic activities with low cytotoxicity (CC50 > 50 µM) in rat cardiomyocytes, underscoring their therapeutic potential.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sesquiterpenos / Miócitos Cardíacos / Sesquiterpenos Policíclicos / Phellinus Limite: Animals Idioma: En Ano de publicação: 2024 Tipo de documento: Article
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sesquiterpenos / Miócitos Cardíacos / Sesquiterpenos Policíclicos / Phellinus Limite: Animals Idioma: En Ano de publicação: 2024 Tipo de documento: Article