Desmoplasia Is Associated with Decreased Cytotoxic and Helper T Cells and Increased T-Cell Exhaustion in Cutaneous Squamous Cell Carcinoma.

Hirakawa, Yuka; Zhan, Qian; Essien, Sernah; Yu, Kenneth K; Murad, Fadi; Piris, Adriano; Ramsey, Matthew R; Schatton, Tobias; Carucci, John A; Schmults, Chrysalyne D

Hirakawa, Yuka; Zhan, Qian; Essien, Sernah; Yu, Kenneth K; Murad, Fadi; Piris, Adriano; Ramsey, Matthew R; Schatton, Tobias; Carucci, John A; Schmults, Chrysalyne D.

Afiliação

Hirakawa Y; Department of Dermatology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Zhan Q; Department of Dermatology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Essien S; Department of Dermatology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Yu KK; Department of Dermatology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Murad F; Department of Dermatology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Piris A; Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Ramsey MR; Department of Dermatology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Schatton T; Department of Dermatology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Carucci JA; Department of Dermatology, New York University School of Medicine, New York, New York, USA.
Schmults CD; Department of Dermatology, Brigham and Women's Hospital, Boston, Massachusetts, USA. Electronic address: cschmults@bwh.harvard.edu.

J Invest Dermatol ; 144(8): 1901-1904.e2, 2024 Aug.

Article em En | MEDLINE | ID: mdl-38309575

Assuntos

Carcinoma de Células Escamosas; Neoplasias Cutâneas; Linfócitos T Citotóxicos; Linfócitos T Auxiliares-Indutores; Idoso; Feminino; Humanos; Masculino; Pessoa de Meia-Idade; Carcinoma de Células Escamosas/imunologia; Carcinoma de Células Escamosas/patologia; Neoplasias Cutâneas/imunologia; Neoplasias Cutâneas/patologia; Exaustão das Células T; Linfócitos T Citotóxicos/imunologia; Linfócitos T Auxiliares-Indutores/imunologia

Palavras-chave

Cutaneous squamous cell carcinoma; Desmoplasia; Immune evasion; T-cell exclusion; T-cell exhaustion

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Cutâneas / Carcinoma de Células Escamosas / Linfócitos T Citotóxicos / Linfócitos T Auxiliares-Indutores Tipo de estudo: Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2024 Tipo de documento: Article

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