Impact of deep muscle invasion on nodal status and survival in patients with pT2 esophageal squamous cancer.
J Surg Oncol
; 129(6): 1056-1062, 2024 May.
Article
em En
| MEDLINE
| ID: mdl-38314575
ABSTRACT
BACKGROUND:
Whether T2 esophageal squamous cell carcinoma should be subclassified remains controversial. We aimed to investigate the impact of the depth of muscularis propria invasion on nodal status and survival outcomes.METHODS:
We identified patients with pT2 esophageal squamous cell carcinoma who underwent primary surgery from January 2009 to June 2017. Clinical data were extracted from prospectively maintained databases. Tumor muscularis propria invasion was stratified into superficial or deep. Binary logistic regression was used to determine risk factors for lymph node metastases. The impact of the depth of muscularis propria invasion on survival was investigated using KaplanâMeier analysis and a Cox proportional hazard regression model.RESULTS:
A total of 750 patients from three institutes were investigated. The depth of muscularis propria invasion (odds ratio [OR] 3.95, 95% confidence interval [CI] 2.46-6.35; p < 0.001) was correlated with lymph node metastases using logistic regression. T substage (hazard ratio [HR] 1.37, 95% CI 1.05-1.79; p < 0.001) and N status (HR 1.51, 95% CI 1.05-2.17; p < 0.001) were independent risk factors in multivariate Cox regression analysis. The deep muscle invasion was associated with worse overall survival (HR 1.52, 95% CI 1.19-1.94; p = 0.001) than superficial, specifically in T2N0 patients (HR 1.38, 95% CI 1.08-1.94; p = 0.035).CONCLUSIONS:
We found that deep muscle invasion was associated with significantly worse outcomes and recommended the substaging of pT2 esophageal squamous cell carcinoma in routine pathological examination.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Esofágicas
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Carcinoma de Células Escamosas do Esôfago
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Metástase Linfática
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Invasividade Neoplásica
Tipo de estudo:
Prognostic_studies
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Risk_factors_studies
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article