Exploring the connection between microsatellite instability and inflammatory indicators in cancers.
Future Oncol
; 20(2): 95-105, 2024 Jan.
Article
em En
| MEDLINE
| ID: mdl-38318682
ABSTRACT
Aim:
This study aimed to investigate the association between microsatellite instability (MSI) status and inflammatory indicators in patients with cancer. Patients &methods:
A total of 204 patients with various cancer diagnoses, including 102 with MSI-high (MSI-H) and 102 with microsatellite stable tumors, were enrolled. Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), C-reactive protein (CRP)-to-albumin ratio and systemic immune-inflammation index were evaluated.Results:
In microsatellite stable patients, NLR, LMR, PLR and systemic immune-inflammation index were significantly linked to worse survival in univariate analysis, and having a LMR ≤2.6 negatively affected survival in multivariate analysis, although these indicators did not affect the survival of MSI-H patients.Conclusion:
The impact of chronic inflammation on survival varies with MSI status. Further research is needed for targeted therapies in different tumors.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Instabilidade de Microssatélites
/
Neoplasias
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article