Rhodium-catalyzed annulation of hydrazines with vinylene carbonate to synthesize unsubstituted 1-aminoindole derivatives.
RSC Adv
; 14(7): 4804-4809, 2024 Jan 31.
Article
em En
| MEDLINE
| ID: mdl-38323018
ABSTRACT
Herein, we describe rhodium-catalysed C-H bond activation for [3 + 2] annulation using hydrazide and vinylene carbonate, providing an efficient method for synthesising unsubstituted 1-aminoindole compounds. Characterised by high yields, mild reaction conditions, and no need for external oxidants, this transformation demonstrates excellent regioselectivity and a wide tolerance for various functional groups.
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MEDLINE
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En
Ano de publicação:
2024
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Article