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The Role of Corticosteroids and Immunomodulatory Therapy in the Management of Infectious Uveitis.
Akhavanrezayat, Amir; Uludag Kirimli, Gunay; Matsumiya, Wataru; Khojasteh, Hassan; Or, Christopher; Karaca, Irmak; Pham, Brandon; Ongpalakorn, Prapatsorn; Lajevardi, Sherin; Lam, Brandon; Hwang, Jaclyn Joyce; Than, Ngoc Trong Tuong; Park, SungWho; Yavari, Negin; Bazojoo, Vahid; Mobasserian, Azadeh; Khatri, Anadi; Halim, Muhammad Sohail; Thng, Zheng Xian; Ghoraba, Hashem; Do, Diana V; Tugal-Tutkun, Ilknur; Gupta, Vishali; de Smet, Marc; Nguyen, Quan Dong.
Afiliação
  • Akhavanrezayat A; Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California, USA.
  • Uludag Kirimli G; Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California, USA.
  • Matsumiya W; Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California, USA.
  • Khojasteh H; Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, Kobe, Japan.
  • Or C; Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California, USA.
  • Karaca I; Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California, USA.
  • Pham B; Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California, USA.
  • Ongpalakorn P; Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California, USA.
  • Lajevardi S; Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California, USA.
  • Lam B; Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California, USA.
  • Hwang JJ; Department of Ophthalmology, University of Texas Health Science Center, San Antonio, Texas, USA.
  • Than NTT; Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California, USA.
  • Park S; Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California, USA.
  • Yavari N; Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California, USA.
  • Bazojoo V; Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California, USA.
  • Mobasserian A; Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California, USA.
  • Khatri A; Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California, USA.
  • Halim MS; Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California, USA.
  • Thng ZX; Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California, USA.
  • Ghoraba H; Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California, USA.
  • Do DV; Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California, USA.
  • Tugal-Tutkun I; Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California, USA.
  • Gupta V; Department of Ophthalmology, Faculty of Medicine, Istanbul University, Istanbul, Turkey.
  • de Smet M; Bayrampasa Eye Hospital, Eye Protection Foundation, Istanbul, Turkey.
  • Nguyen QD; Advanced Eye Center, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Ocul Immunol Inflamm ; : 1-12, 2024 Feb 08.
Article em En | MEDLINE | ID: mdl-38330155
ABSTRACT

PURPOSE:

The index review aims to provide an update on the role of corticosteroids and steroid-sparing immunomodulatory therapy (IMT) in managing patients with infectious uveitis.

METHOD:

Narrative literature review.

RESULTS:

Corticosteroids and immunomodulatory therapy (IMT) focus on the host defense system instead of the pathogen, adjusting exaggerated inflammatory reactions to reduce potential harm to ocular tissues. Systemic or local corticosteroids are primarily selected as adjunctive medication for infectious uveitis. Concomitant corticosteroids have also been used in cases of paradoxical worsening in ocular tuberculosis and immune recovery uveitis in cytomegalovirus (CMV) retinitis. While there is no well-established evidence to support the use of IMT in infectious uveitis, it is occasionally used in clinical settings to treat persistent inflammation following resolution of infection such as cases of ocular tuberculosis and ocular syphilis where an insufficient response is observed with corticosteroids.

CONCLUSION:

There is no consensus on the position of immunomodulatory therapy in the management of infectious uveitis with different etiologies. The index review provides an overview of available adjunctive corticosteroids and IMT options to assist clinicians in managing such disease entities more efficiently.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article