Synthesis of α/ß-Aromatic Peroxy Thiols Mediated by Iodine Source.
J Org Chem
; 89(5): 3049-3057, 2024 Mar 01.
Article
em En
| MEDLINE
| ID: mdl-38332634
ABSTRACT
Peroxygenated compounds have wide applications in various fields, including chemistry, pharmaceutical chemistry, medicine, and materials science. However, there is still a need for more efficient and environmentally friendly synthesis methods for such compounds. Herein, we investigated the two-step, one-pot, regioselective synthesis of α/ß-aromatic peroxy thiols. We explored various substrates and solvents for the reaction and identified the optimal reaction conditions. We successfully obtained several peroxy thiols in moderate to good yields via the selective generation of effective intermediates of iodoalkyl peroxides at room temperature without the need for metal catalysts.
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MEDLINE
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En
Ano de publicação:
2024
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Article