Intranasal drug delivery: The interaction between nanoparticles and the nose-to-brain pathway.
Adv Drug Deliv Rev
; 207: 115196, 2024 04.
Article
em En
| MEDLINE
| ID: mdl-38336090
ABSTRACT
Intranasal delivery provides a direct and non-invasive method for drugs to reach the central nervous system. Nanoparticles play a crucial role as carriers in augmenting the efficacy of brain delivery. However, the interaction between nanoparticles and the nose-to-brain pathway and how the various biopharmaceutical factors affect brain delivery efficacy remains unclear. In this review, we comprehensively summarized the anatomical and physiological characteristics of the nose-to-brain pathway and the obstacles that hinder brain delivery. We then outlined the interaction between nanoparticles and this pathway and reviewed the biomedical applications of various nanoparticulate drug delivery systems for nose-to-brain drug delivery. This review aims at inspiring innovative approaches for enhancing the effectiveness of nose-to-brain drug delivery in the treatment of different brain disorders.
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Base de dados:
MEDLINE
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Encéfalo
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Nanopartículas
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article