Two cases of linagliptin-associated bullous pemphigoid resulting in sepsis and endocarditis.
BMJ Case Rep
; 17(2)2024 Feb 13.
Article
em En
| MEDLINE
| ID: mdl-38350700
ABSTRACT
We describe two patients, in their 70s, each presenting to the emergency department, with 6-week histories of progressively developing pruritic bullae. Both individuals had multiple comorbidities, including type 2 diabetes-for which they took linagliptin, chronic kidney disease, hypertension and prosthetic heart valves. Owing to systemic illness and endocarditis secondary to superadded bacterial infections, they both required intensive treatment and prolonged hospital admissions.Despite the beneficial effect of linagliptin on glycaemic control and its reported cardiovascular and renal safety profiles, we add our cases as evidence of the significant risk of developing bullous pemphigoid while taking this medication. Secondary infection of bullous pemphigoid increased the risk of developing endocarditis, particularly among individuals with a medical history of valve replacement surgery. Considering this, we advocate caution when prescribing this medication.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Penfigoide Bolhoso
/
Sepse
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Diabetes Mellitus Tipo 2
/
Endocardite
Tipo de estudo:
Risk_factors_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article