Visible light-induced C(sp3)-H azolation of ethers via radical-polar crossover.
Chem Commun (Camb)
; 60(19): 2669-2672, 2024 Feb 29.
Article
em En
| MEDLINE
| ID: mdl-38351890
ABSTRACT
Reported herein is a photochemical strategy for C(sp3)-H azolation of ethers via a hydrogen-atom transfer and radical-polar crossover process, offering efficient access to valuable N-alkylated azoles under visible-light irradiation. The protocol is metal-free and photocatalyst-free, and exhibits good to excellent yields and broad substrate scope with regard to azoles. EPR experiments provide evidence for the formation of intermediates formed in situ.
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MEDLINE
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En
Ano de publicação:
2024
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Article