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Construction of an Angular Tricyclic Benzofuran Skeleton Using the C-H Activation Strategy.
Sun, Qianqian; Guo, Feixiang; Liu, Yi; Zhang, Yizhe; Zhang, Kunyi; Wang, Yakun; Gao, Qinghe; Lim, Vuanghao; Duan, Yingchao; Fang, Lizhen.
Afiliação
  • Sun Q; Department of Pharmacy, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan 453003, China.
  • Guo F; School of Pharmacy, Xinxiang Medical University, 601 East Jinsui Avenue, Xinxiang, Henan 453003, P. R. China.
  • Liu Y; Advanced Medical and Dental Institute, Universiti Sains Malaysia, Bertam, Kepala Batas, Penang 13200, Malaysia.
  • Zhang Y; School of Pharmacy, Xinxiang Medical University, 601 East Jinsui Avenue, Xinxiang, Henan 453003, P. R. China.
  • Zhang K; School of Pharmacy, Xinxiang Medical University, 601 East Jinsui Avenue, Xinxiang, Henan 453003, P. R. China.
  • Wang Y; School of Pharmacy, Xinxiang Medical University, 601 East Jinsui Avenue, Xinxiang, Henan 453003, P. R. China.
  • Gao Q; School of Pharmacy, Xinxiang Medical University, 601 East Jinsui Avenue, Xinxiang, Henan 453003, P. R. China.
  • Lim V; School of Pharmacy, Xinxiang Medical University, 601 East Jinsui Avenue, Xinxiang, Henan 453003, P. R. China.
  • Duan Y; School of Pharmacy, Xinxiang Medical University, 601 East Jinsui Avenue, Xinxiang, Henan 453003, P. R. China.
  • Fang L; Advanced Medical and Dental Institute, Universiti Sains Malaysia, Bertam, Kepala Batas, Penang 13200, Malaysia.
J Org Chem ; 89(5): 3304-3308, 2024 Mar 01.
Article em En | MEDLINE | ID: mdl-38356371
ABSTRACT
A protocol for the construction of an angular tricyclic benzofuran skeleton based on the C-H activation strategy has been established. Different phthalide lactones on this skeleton can be easily assembled with various side chains by using C-H activation with aldehydes and subsequent reduction. This skeleton provides a versatile and crucial motif for the total synthesis of naturally occurring angular tricyclic benzofurans and their derivatives. Based on this protocol, the improved total syntheses of daldinin A and annullatin D were achieved in yields of 17.3 and 7.6%, respectively.

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article