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Interfacial Tissue Regeneration with Bone.
Steltzer, Stephanie S; Abraham, Adam C; Killian, Megan L.
Afiliação
  • Steltzer SS; Department of Orthopaedic Surgery, University of Michigan Medical School, Ann Arbor, MI, USA.
  • Abraham AC; Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA.
  • Killian ML; Department of Orthopaedic Surgery, University of Michigan Medical School, Ann Arbor, MI, USA.
Curr Osteoporos Rep ; 22(2): 290-298, 2024 04.
Article em En | MEDLINE | ID: mdl-38358401
ABSTRACT
PURPOSE OF REVIEW Interfacial tissue exists throughout the body at cartilage-to-bone (osteochondral interface) and tendon-to-bone (enthesis) interfaces. Healing of interfacial tissues is a current challenge in regenerative approaches because the interface plays a critical role in stabilizing and distributing the mechanical stress between soft tissues (e.g., cartilage and tendon) and bone. The purpose of this review is to identify new directions in the field of interfacial tissue development and physiology that can guide future regenerative strategies for improving post-injury healing. RECENT

FINDINGS:

Cues from interfacial tissue development may guide regeneration including biological cues such as cell phenotype and growth factor signaling; structural cues such as extracellular matrix (ECM) deposition, ECM, and cell alignment; and mechanical cues such as compression, tension, shear, and the stiffness of the cellular microenvironment. In this review, we explore new discoveries in the field of interfacial biology related to ECM remodeling, cellular metabolism, and fate. Based on emergent findings across multiple disciplines, we lay out a framework for future innovations in the design of engineered strategies for interface regeneration. Many of the key mechanisms essential for interfacial tissue development and adaptation have high potential for improving outcomes in the clinic.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Regeneração Óssea / Matriz Extracelular Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Regeneração Óssea / Matriz Extracelular Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article