Longitudinal support for the correlative triad among aging, dopamine D2-like receptor loss, and memory decline.
Neurobiol Aging
; 136: 125-132, 2024 Apr.
Article
em En
| MEDLINE
| ID: mdl-38359585
ABSTRACT
Dopamine decline is suggested to underlie aging-related cognitive decline, but longitudinal examinations of this link are currently missing. We analyzed 5-year longitudinal data for a sample of healthy, older adults (baseline n = 181, age 64-68 years; 5-year follow-up n = 129) who underwent positron emission tomography with 11C-raclopride to assess dopamine D2-like receptor (DRD2) availability, magnetic resonance imaging to evaluate structural brain measures, and cognitive tests. Health, lifestyle, and genetic data were also collected. A data-driven approach (k-means cluster analysis) identified groups that differed maximally in DRD2 decline rates in age-sensitive brain regions. One group (n = 47) had DRD2 decline exclusively in the caudate and no cognitive decline. A second group (n = 72) had more wide-ranged DRD2 decline in putamen and nucleus accumbens and also in extrastriatal regions. The latter group showed significant 5-year working memory decline that correlated with putamen DRD2 decline, along with higher dementia and cardiovascular risk and a faster biological pace of aging. Taken together, for individuals with more extensive DRD2 decline, dopamine decline is associated with memory decline in aging.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Envelhecimento
/
Dopamina
Tipo de estudo:
Risk_factors_studies
Limite:
Aged
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Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article