Triplet Energy Transfer Mechanism in Copper Photocatalytic N- and O-Methylation.
Chemistry
; 30(22): e202400560, 2024 Apr 16.
Article
em En
| MEDLINE
| ID: mdl-38363220
ABSTRACT
Methylation reactions are chemically simple but challenging to perform under mild and non-toxic conditions. A photochemical energy transfer strategy was merged with copper catalysis to enable fast reaction times of minutes and broad applicability to N-heterocycles, (hetero-)aromatic carboxylic acids, and drug-like molecules in high yields and good functional group tolerance. Detailed mechanistic investigations, using kinetic analysis, aprotic MS, UV/Vis, and luminescence quenching experiments revealed a triplet-triplet energy transfer mechanism between hypervalent iodine(III) reagents and readily available photosensitizers.
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MEDLINE
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En
Ano de publicação:
2024
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Article