Anti-Ferroptotic Effect of Cannabidiol in Human Skin Keratinocytes Characterized by Data-Independent Acquisition-Based Proteomics.
J Nat Prod
; 87(5): 1493-1499, 2024 May 24.
Article
em En
| MEDLINE
| ID: mdl-38373879
ABSTRACT
Skin cells are susceptible to oxidative stress and various types of cell death, including an iron-dependent form known as ferroptosis. Cannabidiol (CBD) can protect skin cells against oxidative stress, but whether this is attributed to the inhibition of ferroptosis is unknown. Herein, we evaluated the anti-ferroptotic effect of CBD in human keratinocytes using biochemical assays (radical scavenging and iron chelating) and cell-based models (for lipid peroxidation and intracellular iron). CBD's anti-ferroptotic effect was further characterized by proteomic analysis. This study identifies anti-ferroptosis as a mechanism of CBD's skin protective effects.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Canabidiol
/
Queratinócitos
/
Proteômica
/
Ferroptose
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article