Hydroxychloroquine Induced Cardiotoxicity: A Case Series.
Rom J Intern Med
; 62(2): 210-215, 2024 Jun 01.
Article
em En
| MEDLINE
| ID: mdl-38377065
ABSTRACT
Hydroxychloroquine (HCQ) induced cardiotoxicity is a rare diagnosis and is often associated with chronic use of the medication. It has been shown that chronic HCQ use is associated with a drug-induced cardiomyopathy mainly driven by acquired lysosomal storage defects leading to hypertrophy and conduction abnormalities. As the only proven treatment is the discontinuation of the offending agent, prompt recognition is required to avoid further exposure to the drug and potential progression of disease. History, physical examination and advanced imaging modalities are useful diagnostic tools, but more invasive testing with an endomyocardial biopsy is required for definitive diagnosis. We present a descriptive case series of ten patients that were diagnosed with biopsy proven HCQ cardiotoxicity.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Antirreumáticos
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Cardiotoxicidade
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Hidroxicloroquina
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article