Compression therapy using surgical gloves is ineffective for the prevention of vincristine-induced neuropathy in patients with malignant lymphoma.
Support Care Cancer
; 32(3): 173, 2024 Feb 20.
Article
em En
| MEDLINE
| ID: mdl-38378914
ABSTRACT
PURPOSE:
Vincristine (VCR) often induces peripheral neuropathy (PN) as an adverse event. Currently, there is no consensus on the prevention of vincristine-induced PN (VIPN). In this study, we aimed to investigate the efficacy of compression therapy using surgical gloves for preventing VIPN.METHODS:
Patients with malignant lymphoma (vincristine-naïve) who were receiving chemotherapy with cyclophosphamide, doxorubicin, VCR, and prednisolone, with or without rituximab, every 3 weeks for six cycles were eligible. For every VCR infusion, each patient wore two one-size-smaller gloves on one hand (study hand) for 90 min. The other hand was left bare (control hand). PN was assessed at each treatment using the Common Terminology Criteria for Adverse Events ver. 4.0.RESULTS:
Fifty-one patients with malignant lymphoma were enrolled and 44 were evaluated. At 1 month after treatment, the occurrence rates of grade ≥ 2 sensory PN were 13.6 and 13.6% in the study and control hands, respectively (p = 1.0), and those of grade ≥ 2 motor PN were 15.9 and 15.9% in the study and control hands, respectively (p = 1.0).CONCLUSION:
Compression therapy using surgical gloves showed no significant effect for the prevention of VIPN. TRIAL REGISTRATION November 1, 2018, National University Hospital Council of Japan (UMIN 000034145).Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Linfoma Difuso de Grandes Células B
/
Doenças do Sistema Nervoso Periférico
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article