Plasma-treated collagen functionalized with chondroitin sulfate as bioactive and nanostructured extracellular matrix mimics.
Nanomedicine (Lond)
; 19(9): 799-810, 2024 04.
Article
em En
| MEDLINE
| ID: mdl-38385248
ABSTRACT
Aim:
Cell microenvironment contains a plethora of information that influences cell modulation. Indeed, the extracellular matrix plays a central role in tissue development. Reproducing the cell-extracellular matrix crosstalk able to recapitulate both physical and biochemical signals is crucial to obtain functional tissue models or regenerative strategies. Materials &methods:
Here, a combined method is proposed to easily functionalize collagen surface films, tailoring morphological properties. Oxygen nonthermal plasma treatment and glyco-conjugation with chondroitin sulfate are used to modify surface properties.Results:
It results in higher adhesion, proliferation and morphological organization of U87 glioblastoma cells.Conclusion:
Our finding suggests new promising strategies for the development of collagen-based biomaterials, which can be employed for advanced in vitro models.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sulfatos de Condroitina
/
Colágeno
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article