Development of on-DNA Formation of Benzofuran for DNA-Encoded Library Synthesis.
Org Lett
; 26(8): 1688-1693, 2024 Mar 01.
Article
em En
| MEDLINE
| ID: mdl-38385779
ABSTRACT
Using a novel homologation-heterocyclization cascade, the on-DNA synthesis of benzofurans from aldehydes has been developed. The methodology, based on an innovative use of the Seyferth-Gilbert homologation, followed by a high yielding Sonogashira coupling in situ intramolecular cyclization one-pot, two-step reaction, provides a powerful and unique pathway for DNA-encoded library (DEL) synthesis of a wide array of pharmaceutically relevant benzofuran-based scaffolds.
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Base de dados:
MEDLINE
Assunto principal:
Benzofuranos
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article