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Redoxisome Update: TRX and TXNIP/TBP2-Dependent Regulation of NLRP-1/NLRP-3 Inflammasome.
Yoshihara, Eiji; Matsuo, Yoshiyuki; Masaki, So; Chen, Zhe; Tian, Hai; Masutani, Hiroshi; Yamauchi, Akira; Hirota, Kiichi; Yodoi, Junji.
Afiliação
  • Yoshihara E; The Lundquist Institute for Biomedical Innovation, Harbor-UCLA Medical Center, Torrance, California, USA.
  • Matsuo Y; David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, USA.
  • Masaki S; Department of Human Stress Response Science, Institute of Biomedical Science, Kansai Medical University, Hirakata, Osaka, Japan.
  • Chen Z; Laboratory of Cellular Biochemistry, Department of Animal Resource Sciences, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Tokyo, Japan.
  • Tian H; Revolution Medicines, Redwood City, California, USA.
  • Masutani H; Department of Basic Medicine, Medical College, Shaoxing University, Shaoxing, China.
  • Yamauchi A; Tenri University, Faculty of Health Care Department of Clinical Laboratory Science, Tenri, Nara, Japan.
  • Hirota K; Department of Breast Surgery, Misugikai Sato Hospital, Hirakata, Osaka, Japan.
  • Yodoi J; Department of Pain Clinic Medicine, Minamiuonuma City Hospital, Minamiuonuma, Niigata, Japan.
Antioxid Redox Signal ; 40(10-12): 595-597, 2024 Apr.
Article em En | MEDLINE | ID: mdl-38386512
ABSTRACT
Recent studies have provided evidence for the direct binding of thioredoxin-1 (TRX1) to a component of inflammasome complex NLR family pyrin domain containing 1 (NLRP-1). This interaction suggests a potential role for TRX1 in the regulation of the NLRP-1 inflammasome. Furthermore, the NLRP-3 inflammasome is known to bind TRX1 and its inhibitor, TRX-binding protein-2/TRX-interacting protein/vitamin D3 upregulated protein-1 (TBP2/TXNIP/VDUP-1). This binding forms a redox-sensitive complex, termed the "Redoxisome," as described previously. However, the specific functions of NLRP-1 within the redoxisome complex remain undefined. Antioxid. Redox Signal. 40, 595-597.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inflamassomos / Proteína 3 que Contém Domínio de Pirina da Família NLR Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inflamassomos / Proteína 3 que Contém Domínio de Pirina da Família NLR Idioma: En Ano de publicação: 2024 Tipo de documento: Article