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Incidence rates of thrombosis with thrombocytopenia syndrome (TTS) among adults in United States commercial and Medicare claims databases, 2017-2020.
Lloyd, Patricia C; Lufkin, Bradley; Moll, Keran; Ogilvie, Rachel P; McMahill-Walraven, Cheryl N; Beachler, Daniel C; Kelman, Jeffrey A; Shi, Xiangyu; Hobbi, Shayan; Amend, Kandace L; Djibo, Djeneba Audrey; Shangguan, Shanlai; Shoaibi, Azadeh; Sheng, Minya; Secora, Alex; Zhou, Cindy Ke; Kowarski, Lisa; Chillarige, Yoganand; Forshee, Richard A; Anderson, Steven A; Muthuri, Stella; Seeger, John D; Kline, Annemarie; Reich, Christian; MaCurdy, Thomas; Wong, Hui Lee.
Afiliação
  • Lloyd PC; US Food and Drug Administration, Silver Spring, MD, USA. Electronic address: patricia.lloyd@fda.hhs.gov.
  • Lufkin B; Acumen LLC, Burlingame, CA, USA.
  • Moll K; IBM Consulting, Bethesda, MD, USA.
  • Ogilvie RP; Optum Epidemiology, Boston, MA, USA.
  • McMahill-Walraven CN; CVS Health, Blue Bell, PA, USA.
  • Beachler DC; Carelon Research, Wilmington, DE, USA.
  • Kelman JA; Centers for Medicare & Medicaid Services, Baltimore, MD, USA.
  • Shi X; Acumen LLC, Burlingame, CA, USA.
  • Hobbi S; IBM Consulting, Bethesda, MD, USA.
  • Amend KL; Optum Epidemiology, Boston, MA, USA.
  • Djibo DA; CVS Health, Blue Bell, PA, USA.
  • Shangguan S; Acumen LLC, Burlingame, CA, USA.
  • Shoaibi A; US Food and Drug Administration, Silver Spring, MD, USA.
  • Sheng M; IBM Consulting, Bethesda, MD, USA.
  • Secora A; IQVIA, Falls Church, VA, USA.
  • Zhou CK; US Food and Drug Administration, Silver Spring, MD, USA.
  • Kowarski L; IBM Consulting, Bethesda, MD, USA.
  • Chillarige Y; Acumen LLC, Burlingame, CA, USA.
  • Forshee RA; US Food and Drug Administration, Silver Spring, MD, USA.
  • Anderson SA; US Food and Drug Administration, Silver Spring, MD, USA.
  • Muthuri S; IBM Consulting, Bethesda, MD, USA.
  • Seeger JD; Optum Epidemiology, Boston, MA, USA.
  • Kline A; CVS Health, Blue Bell, PA, USA.
  • Reich C; IQVIA, Falls Church, VA, USA.
  • MaCurdy T; Acumen LLC, Burlingame, CA, USA; Department of Economics, Stanford University, Stanford, CA, USA.
  • Wong HL; US Food and Drug Administration, Silver Spring, MD, USA.
Vaccine ; 42(8): 2004-2010, 2024 Mar 19.
Article em En | MEDLINE | ID: mdl-38388240
ABSTRACT

BACKGROUND:

Increased risk of thrombosis with thrombocytopenia syndrome (TTS) following adenovirus vector-based COVID-19 vaccinations has been identified in passive surveillance systems. TTS incidence rates (IRs) in the United States (U.S.) are needed to contextualize reports following COVID-19 vaccination.

METHODS:

We estimated annual and monthly IRs of overall TTS, common site TTS, and unusual site TTS for adults aged 18-64 years in Carelon Research and MarketScan commercial claims (2017-Oct 2020), CVS Health and Optum commercial claims (2019-Oct 2020), and adults aged ≥ 65 years using CMS Medicare claims (2019-Oct 2020); IRs were stratified by age, sex, and race/ethnicity (CMS Medicare).

RESULTS:

Across data sources, annual IRs for overall TTS were similar between Jan-Dec 2019 and Jan-Oct 2020. Rates were higher in Medicare (IRs 370.72 and 365.63 per 100,000 person-years for 2019 and 2020, respectively) than commercial data sources (MarketScan IRs 24.21 and 24.06 per 100,000 person-years; Optum IRs 32.60 and 31.29 per 100,000 person-years; Carelon Research IRs 24.46 and 26.16 per 100,000 person-years; CVS Health IRs 30.31 and 30.25 per 100,000 person-years). Across years and databases, common site TTS IRs increased with age and were higher among males. Among adults aged ≥ 65 years, the common site TTS IR was highest among non-Hispanic black adults. Annual unusual site TTS IRs ranged between 2.02 and 3.04 (commercial) and 12.49 (Medicare) per 100,000 person-years for Jan-Dec 2019; IRs ranged between 1.53 and 2.67 (commercial) and 11.57 (Medicare) per 100,000 person-years for Jan-Oct 2020. Unusual site TTS IRs were higher in males and increased with age in commercial data sources; among adults aged ≥ 65 years, IRs decreased with age and were highest among non-Hispanic American Indian/Alaska native adults.

CONCLUSION:

TTS IRs were generally similar across years, higher for males, and increased with age. These rates may contribute to surveillance of post-vaccination TTS.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Trombocitopenia / Trombose / COVID-19 Limite: Adult / Aged / Humans / Male País como assunto: America do norte Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Trombocitopenia / Trombose / COVID-19 Limite: Adult / Aged / Humans / Male País como assunto: America do norte Idioma: En Ano de publicação: 2024 Tipo de documento: Article