Long-lasting forms of plasticity through patterned ultrasound-induced brainwave entrainment.
Sci Adv
; 10(8): eadk3198, 2024 Feb 23.
Article
em En
| MEDLINE
| ID: mdl-38394205
ABSTRACT
Achieving long-lasting neuronal modulation with low-intensity, low-frequency ultrasound is challenging. Here, we devised theta burst ultrasound stimulation (TBUS) with gamma bursts for brain entrainment and modulation of neuronal plasticity in the mouse motor cortex. We demonstrate that two types of TBUS, intermittent and continuous TBUS, induce bidirectional long-term potentiation or depression-like plasticity, respectively, as evidenced by changes in motor-evoked potentials. These effects depended on molecular pathways associated with long-term plasticity, including N-methyl-d-aspartate receptor and brain-derived neurotrophic factor/tropomyosin receptor kinase B activation, as well as de novo protein synthesis. Notably, bestrophin-1 and transient receptor potential ankyrin 1 play important roles in these enduring effects. Moreover, pretraining TBUS enhances the acquisition of previously unidentified motor skills. Our study unveils a promising protocol for ultrasound neuromodulation, enabling noninvasive and sustained modulation of brain function.
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Base de dados:
MEDLINE
Assunto principal:
Ondas Encefálicas
/
Plasticidade Neuronal
Limite:
Animals
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article