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Myconoside and Calceolarioside E Restrain UV-Induced Skin Photoaging by Activating NRF2-Mediated Defense Mechanisms.
Stoykova, Iva D; Koycheva, Ivanka K; Binev, Biser K; Mihaylova, Liliya V; Benina, Maria Y; Alipieva, Kalina I; Georgiev, Milen I.
Afiliação
  • Stoykova ID; Center of Plant Systems Biology and Biotechnology, 4000 Plovdiv, Bulgaria.
  • Koycheva IK; Laboratory of Metabolomics, Institute of Microbiology, Bulgarian Academy of Sciences, 139 Ruski Blvd., 4000 Plovdiv, Bulgaria.
  • Binev BK; Laboratory of Metabolomics, Institute of Microbiology, Bulgarian Academy of Sciences, 139 Ruski Blvd., 4000 Plovdiv, Bulgaria.
  • Mihaylova LV; Laboratory of Metabolomics, Institute of Microbiology, Bulgarian Academy of Sciences, 139 Ruski Blvd., 4000 Plovdiv, Bulgaria.
  • Benina MY; Center of Plant Systems Biology and Biotechnology, 4000 Plovdiv, Bulgaria.
  • Alipieva KI; Laboratory of Metabolomics, Institute of Microbiology, Bulgarian Academy of Sciences, 139 Ruski Blvd., 4000 Plovdiv, Bulgaria.
  • Georgiev MI; Center of Plant Systems Biology and Biotechnology, 4000 Plovdiv, Bulgaria.
Int J Mol Sci ; 25(4)2024 Feb 19.
Article em En | MEDLINE | ID: mdl-38397118
ABSTRACT
Chronic and excessive ultraviolet (UVA/UVB) irradiation exposure is known as a major contributor to premature skin aging, which leads to excessive reactive oxygen species generation, disturbed extracellular matrix homeostasis, DNA damage, and chronic inflammation. Sunscreen products are the major preventive option against UVR-induced photodamage, mostly counteracting the acute skin effects and only mildly counteracting accelerated aging. Therefore, novel anti-photoaging and photopreventive compounds are a subject of increased scientific interest. Our previous investigations revealed that the endemic plant Haberlea rhodopensis Friv. (HRE) activates the antioxidant defense through an NRF2-mediated mechanism in neutrophiles. In the present study, we aimed to investigate the photoprotective potential of HRE and two of its specialized compounds-the phenylethanoid glycosides myconoside (MYC) and calceolarioside E (CAL)-in UVA/UVB-stimulated human keratinocytes in an in vitro model of photoaging. The obtained data demonstrated that the application of HRE, MYC, and CAL significantly reduced intracellular ROS formation in UVR-exposed HaCaT cells. The NRF2/PGC-1α and TGF-1ß/Smad/Wnt signaling pathways were pointed out as having a critical role in the observed CAL- and MYC-induced photoprotective effect. Collectively, CAL is worth further evaluation as a potent natural NRF2 activator and a promising photoprotective agent that leads to the prevention of UVA/UVB-induced premature skin aging.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dermatopatias / Ácidos Cafeicos / Envelhecimento da Pele / Glucosídeos Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dermatopatias / Ácidos Cafeicos / Envelhecimento da Pele / Glucosídeos Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article