Protection against ß-N-methylamino-l-alanineê·induced vesicular monoamine transporter 2 inhibition by hydroxyl-containing proteinogenic amino acids.
Environ Toxicol Pharmacol
; 107: 104399, 2024 Apr.
Article
em En
| MEDLINE
| ID: mdl-38403141
ABSTRACT
ß-N-methylamino-l-alanine (BMAA) has been shown to inhibit vesicular monoamine transporter 2 (VMAT2), thereby preventing the uptake of monoaminergic neurotransmitters into platelet dense granules and synaptic vesicles. The inhibition is hypothesized to be through direct association of BMAA with hydroxyl groupê·containing amino acid residues in VMAT2. This study evaluated whether BMAA-induced inhibition of VMAT2 could be prevented directly by co-incubation of BMAA with amino acids, and if this protection was specific for BMAA inhibition of VMAT2. l-tyrosine, and to a lesser extent l-serine, was able to prevent BMAA-induced VMAT2 inhibition in a concentration-dependent manner, whereas neither l-threonine nor amino acids without side chain hydroxyl groups could reduce this inhibition. Reserpine-induced VMAT2 inhibition was unaffected by any of the amino acids. These data support the hypothesized interaction between BMAA and hydroxyl groupê·containing amino acids and suggests that this interaction might be leveraged to protect against the toxicity of BMAA.
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Base de dados:
MEDLINE
Assunto principal:
Aminoácidos
/
Diamino Aminoácidos
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article