A causal relationship between appendicular lean mass and atrial fibrillation: A two sample Mendelian randomization study.
Nutr Metab Cardiovasc Dis
; 34(6): 1361-1370, 2024 Jun.
Article
em En
| MEDLINE
| ID: mdl-38403485
ABSTRACT
BACKGROUND AND AIM:
The relationship between appendicular lean mass (ALM) and most cardiovascular events has been established, but the direct association between ALM and atrial fibrillation (AF) remains uncertain. METHODS ANDRESULTS:
Herein, we identified 494 single-nucleotide polymorphisms (SNPs) strongly associated with ALM as instrumental variables (P < 5E-8) based on a genome-wide association study (GWAS) with 450,243 European participants. Then, we employed five Mendelian randomization (MR) analysis methods to investigate the causal relationship between ALM and AF. All results indicated a causal relationship between ALM and AF, among Inverse variance weighted (P = 8.44E-15, odds ratio [OR] 1.16, 95 % confidence interval [CI] 1.114-1.198). Furthermore, we performed a sensitivity analysis, which revealed no evidence of pleiotropy (egger_intercept = 0.000089, P = 0.965) or heterogeneity (MR Egger, Q Value = 0.980; Inverse variance weighted, Q Value = 0.927). The leave-one-out method demonstrates that individual SNPs have no driven impact on the whole causal relationship. Multivariable MR analysis indicates that, after excluding the influence of hypertension and coronary heart disease, a causal relationship between ALM and AF still exists (P = 7.74E-40, OR 95 %CI 1.389 (1.323-1.458)). Importantly, the Radial MR framework analysis and Robust Adjusted Profile Score (RAPS) further exhibit the robustness of this causal relationship.CONCLUSION:
A strong association between ALM and AF was confirmed, and high ALM is a risk factor for AF.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Fenótipo
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Fibrilação Atrial
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Predisposição Genética para Doença
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Polimorfismo de Nucleotídeo Único
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Estudo de Associação Genômica Ampla
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Análise da Randomização Mendeliana
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article